Calmodulin interactions with Cav1 and Cav2 voltage-gated calcium channel IQ domains
نویسندگان
چکیده
† Cardiovascular Research Institute, University of California, San Francisco, CA 94158-2330, USA ‡ Departments of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158-2330, USA § California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA 94158-2330, USA §§ Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
منابع مشابه
Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain.
In neurons, binding of calmodulin (CaM) or calcium-binding protein 1 (CaBP1) to the CaV1 (L-type) voltage-gated calcium channel IQ domain endows the channel with diametrically opposed properties. CaM causes calcium-dependent inactivation and limits calcium entry, whereas CaBP1 blocks calcium-dependent inactivation (CDI) and allows sustained calcium influx. Here, we combine isothermal titration ...
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تاریخ انتشار 2011